Federal State Educational Institution of Higher Professional Training

RUSSIAN STATE UNIVERSITY OF PHYSICAL EDUCATION, SPORT AND TOURISM (RGUFKSMIT)

Sport Research Institute

RESEARCH REPORT

Effect of Taxifolin (Dihydroquercetin) on physical work capacity in top athletes practicing cyclic sports

Project Director S.K. Sarsania, M.D., Prof.

INTRODUCTION

Topicality of the research. Professional sport training and participation in competitions involve strenuous efforts and constantly growing training loads to be executed by athletes. For this reason we feel the need to detect and investigate specific factors, which may help improve physical work capacity in top athletes and speed up the recovery after training exertion. On the one hand, these factors are related to optimal planning of both competition and training loads according to biological adaptation laws with the use of pharmacological support. On the other hand, these factors comprise efficient recovery of the organism after physical training. The recovery process is based on well-balanced nutrition and intake of food supplements of high biological value and high metabolic capacity, which intensify the synthesis of morphological structures and activate favourable physiological reactions. In a long list of biologically active additives, we found it interesting to study a product with the trade name Taxifolin, chemical name (Dihydroquercetin)-98%, produced by the company "Taxifolia" Ltd., Belgorod (Registration #77.99.11.3..7914.8.09; date of registration 24.08.2009). A preliminary information study showed that this product might be called a model antioxidant free of admixtures (pitches, essential oils), its purity being not less than 98%. The base substance is found in the bottom part of Siberian larch and Dahurian larch [18].

Principal properties of Taxifolin:

improvement of microcirculation;

preventing thrombus formation;

enhancement of work capacity and intensification of recovery processes after high physical and psycho-emotional loads;

strengthening of capillary walls;

bringing triglycerides and cholesterol concentrations in blood to normal level;

improvement of coronary blood flow and myocardial contractility, normalization of excitability and conductivity in cardiomyocytes.

Hypothesis. Taking into account the ability of Taxifolin to protect capillaries and improve microcirculation, we suggest that the use of Taxifolin increases oxygen supply and utilization in skeletal muscles, thus resulting in development of aerobic capacities and growth of results in endurance sports.

Purpose. The purpose of our research was to estimate short-term and long-term effects of Taxifolin intake on aerobic capacity of working muscles, functional capacity of the cardiovascular system, and short-term recovery after maximal physical exertion.

Subjects. 5 top-class male athletes (Masters of Sport; Masters of sport, International Class) participated in the research. The age of the subjects varied from 23 to 28 years; all the subjects have been practicing skiing, cycling, and mountain running for many years.

Object of investigation: aerobic capacity of skeletal muscles and functional capacity of the cardiovascular system.

Principal tasks:

1. estimate short-term adaptive effects of Taxifolin intake on 1) functional capacity of the cardiovascular system at rest and 2) immediate recovery of physiological parameters after physical exertion;

2. estimate long-term adaptive effects of Taxifolin intake on 1) functional capacity of the cardiovascular system at rest and 2) immediate recovery of physiological parameters after physical exertion;

3. estimate short-term adaptive effects of Taxifolin intake on aerobic capacity of skeletal muscles;

4. estimate long-term adaptive effects of Taxifolin intake on aerobic capacity of skeletal muscles.