About Taxifolin
The bioflavonoid dihydroquercetin (taxifolin) is the most promising natural antioxidant. The initial raw material is the wood of Siberian and Dahurian larches which grow abundantly and can provide steady supply.
The antioxidative activity of taxifolin exceeds that of most common antioxidants such as tocopherols (vitamin E) and carotenoids (vitamin A). In addition, taxifolin is much more resistant to the effects of oxidation and light.
Health benefits of taxifolin include capillary, liver, and radiation protection. By «trapping» free radicals, taxifolin helps to protect the body against adverse environmental factors. Regular consumption of taxifolin helps to sustain antioxidant reserves in the human body. Exhaustion of these reserves may be caused by an unbalanced diet and environmental factors. As a consequence, the human organism experiences oxidative stress, which may result in different pathologies.
The daily physiological need for bioflavonoids (natural antioxidants) equates to 150-250 mg for children over 7 years of age and 200-250 mg for adults (according to Guidelines MR −08 Physiological Needs for Energy and Nutrition of Different Population Groups within the Russian Federation).
Toxicological studies demonstrated that taxifolin is non-toxic and produces no side effects in human organism.
Daily consumption of taxifolin helps to maintain the body’s physiological functions at high levels.

Taxifolin Activity

Dihydroquercetin (taxifolin, 3,5,7,3’,4’-pentahydroxyffavanone) /CAS No. 480-18-2/ is one of the most powerful antioxidants of natural origin.









Dihydroquercetin was discovered in 1936, by Albert, an American biochemist. Since then, its biological and antioxidative activities have been studied for several decades. More active than tocopherol and carotene, it is also more stable. Dihydroquercetin belongs to a limited flavanone class of flavonoid compounds. It is a fine crystalline or amorphous powder of white to white-cream color depending on the method of preparation and the presence of other substances.

Dihydroquercetin has a good solubility in acetone, methyl and ethyl alcohol, 1,2-propylene glycol, acetic ether, and hydrocarbons, but is insoluble in chloroform, sulphuric ether, and hydrocarbons. The solubility in water increases when more pure dihydroquercetin is used. While conventional commercial products have a solubility of 0.1 percent by weight at 20oC and 5.20 percent by weight at 90oC, highly purified dihydroquercetin provides more than threefold increase over these solubility levels (see below).

Basic Physical and Chemical Properties of Taxifolin

Molecular formula — С15Н1207
Molecular weight — 304.25 daltons
Melting point: 222 — 224oС. Buchi, Melting Point B-250
UV spectrum: λmax=289±2nm, log Emax=4.25±0.05.

A solution of 0.1 g of dihydroquercetin in 5 ml of 95% alcohol, with 0.5 ml of concentrated chlorohydric acid and 0.05 g of granulated zinc added, yields a crimson color, signifying the presence of the flavanoid (flavonoid qualitative test).

Although there are a considerable number of patents related to the extraction of dihydroquercetin, no adequate technology has been available to achieve the high purification of the substance until now. Solvent reprecipitation methods result in an amorphous product with a tar-like residue, which is impossible to identify. This is responsible for the low solubility of dihydroquercetin even in hot water.

Standard Chromatogram of Highly Purified Taxifolin

Dihydroquercetin 99.6%
Aromadendrin 0.40%
Eriodictyol 0%
Naringenin 0%

Analysis Conditions:
Column: 4.6×250 mm, Kromasil-100-C18, 5 µm
Eluent: A — ACN/2%CH3COOH (30:70), B — 100% ACN
Gradient: from 100% A to 100% B in 13 min
Detection: UV-288 nm
Flow rate: 1 ml/min
Injection — 10 µl

Higher purity of dihydroquercetin result to significant impact on its physical and chemical properties. Dihydroquercetin, as part of bioflavonoid complex, differs from the other known products because of its ability to become crystallized in highly pure state.

Taxifolin Crystals:










The removal of foreign substances improves significantly its solubility as compared to the solubility of the other known products. Such significant modifications in physical and chemical properties show that dihydroquercetin manufactured using this new technology can be considered as new generation product with new technological possibilities and expanded applications.